In case series, there is insufficient information on dose and duration of taking HSW of each patient, but some articles indicate that the majority of patients take Chinese patent medicine in accordance with the instructions. Because case series is summary report for multiple patients and because of the lack of description of the individual patient information, the following is mainly an analysis of case reports. Results. High cholesterol 4. Xiang Lei, Jing Chen, Jingtian Ren, Yan Li, Jingbo Zhai, Wei Mu, Li Zhang, Wenke Zheng, Guihua Tian, Hongcai Shang, "Liver Damage Associated with Polygonum multiflorum Thunb. Based on the above information we know that HSW associated with liver injury can occur at any age group and with no gender orientation. USA.gov. This review covers a to… Evid Based Complement Alternat Med. Mechanism research of stilbene glucoside from Polygonum multiflovum thunb on hyperlipemia. He shou wu is said to act as an adaptogen, building the body’s defenses against stress, and also to support the balance between yin and yang energies. Brief Answer: Information Detailed Answer: Hello XXXXXXX Fo-Ti is a stimulant laxative, which would explain the diarrhea and abdominal cramps if that is the nature of your stomach pain. If fatigue, anorexia, nausea, yellowing of skin and sclera, yellow urine, and other symptoms appear after medication, patients should be alerted to the occurrence of liver damage and promptly stop the medicine and treatment. Differences can be resolved through discussion. Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been reported to induce inflammation‐associated idiosyncratic liver injury. These terms were searched as free-text in the title or the abstract. Methods. Sun, “One case of severe liver damage caused by Chinese drugs for invigoration,”, J. Y. Yang, “One case of liver damage caused by, G. J.-H. Park, S. P. Mann, and M. C. Ngu, “Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum,”, Z. H. Li, D. M. Gai, and X. R. Zhuang, “Hepatitis attributed to, D. M. Fan and Z. L. Zhou, “One case of liver damage caused by, F. X. Li, “One case of liver injury caused by Shou-Wu-Wan,”, W. F. Zhang, “One case of liver injury caused by Huo-Li-Su,”, J. H. Niu, “One case of severe liver damage caused by Shou-Wu-Pian,”, M. H. He and X. J. Zhen, “Two cases of acute liver damage caused by, P. P.-H. Case reports and case series are included in the review if they reported factual data on liver damage related to HSW. Polygonum Multiflorum for Liver Health Animal research shows that P. multiflorum reduces fat deposits inside the liver. This review covers a total of 450 cases in 76 articles. The HSW forms of case reports are shown in Table 4; in terms of usage, all involved Chinese patent medicines are of oral formulation; the types of HSW decoction pieces used included tea, liquor, powder, and decoction. Toxins (Basel). Objective. People should be alert to liver damage when taking HSW preparations. In case series, seven articles reported 53 (53/138, 38.4%) cases with liver damage related to HSW many times [17, 21, 27, 29–31]. Traditional Chinese herbal medicine ordinarily recommends the use of herbs in complex formulas, but HSW is also often taken as a single herb. Background & aims: Polygonum Multiflorum Thumb (PMT), an ancient anti-aging Chinese herb known traditionally as He Shou Wu, has side effects of liver toxicity. UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicity and Nephrotoxicity in Rats Induced by. One additional reference was identified while searching reference lists of the included papers. An extensive search of 6 medical databases was performed up to June 2014. Case reports and case series involving liver damage associated with HSW were included. Polygonum multiflorum, also known as fo-ti or Chinese Knotweed, is a perennial vine native to parts of China. The herb, scientifically known as Polygonum multiflorum, is known to be … Modern pharmacological studies have shown that HSW have the effect of reducing blood lipid and antiarteriosclerosis [3–5], protecting liver [6, 7], enhancing immunologic [8, 9], improving memory, protecting nerve cells, and increasing intelligence [10, 11], antioxidation, antiaging [12, 13], and so forth. In June 2014, we searched the following Chinese-language electronic databases: Chinese Biomedical Literature Database (CBM, 1980–2014), Chinese Journal Full-Text Database (CNKI, 1980–2014), Weipu Journal Database (VIP, 1989–2014), and Wanfang Data (1990–2014) and two English-language databases PubMed and EMBASE (1989–2014). NLM Epub 2017 Jan 24. He Shou Wu benefits the health of your kidney and liver and supports the … The news article reporting the death of the student did not reveal if he suffered from a known liver condition. Immune function 6. However, although PM extracts are generally considered to be relatively safe, PM extracts may still show hepatotoxicity. ACS Omega. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. Some studies suggested that the adverse reactions of traditional Chinese medicine are closely related to patient self-medication, arbitrarily increase in the dose, or long-term use [39–41]; this systematic review and some papers included in it also have the same standpoint. See this image and copyright information in PMC. : A Systematic Review of Case Reports and Case Series Xiang Lei, 1 Jing Chen, 1 Jingtian Ren, 2 Yan Li, 1 Jingbo Zhai, 1 Wei Mu, 3 Li Zhang, 3 (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Chinese Pharmacopoeia. This study aimed to identify the genetic basis of susceptibility to PM‐drug‐induced liver … Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Retrospective analysis on cases of liver injury of Polygonum multiflorum. So the diarrhea may not be a sign of liver damage… Copyright © 2015 Xiang Lei et al. This review covers a total of 450 cases in 76 articles. Blood lipid-regulation of stilbene glycoside from Polygonum multiflorum . multiflorum causes embryonic toxicity in mice and may affect embryonic … In total, 450 cases of hepatitis associated with HSW were reported. Polygonum multiflorum … Liver and Kidney Health. Two authors (Xiang Lei and Jing Chen) independently examined the titles and abstracts of all papers found through the search to determine if they fulfilled the inclusion criteria outlined above. The references of relevant reviews and the included literatures were checked for possible identification of additional studies. Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim H, Kim HJ. Fo-ti has been linked to liver damage in several reports, including … COVID-19 is an emerging, rapidly evolving situation. NA: not available; H: hepatocellular; C: cholestatic; M: mixed; LT: liver transplantation. Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb. In 72 cases of case reports, patients ranged in age from 5 to 78 years, with a median of 36.5. Epub 2017 Mar 29. After screening, articles were read in full and extracted by two independent reviewers (Xiang Lei and Jing Chen). Gao X., Hu Y.-J., Fu L.-C. Legend says that fo-ti was discovered by a Chinese man, Mr. After admission examination, a few cases were found with epigastrium tenderness, first percussion over the liver, hepatomegaly or splenomegaly, and even ascites [17, 19, 23]. The reasons for medication of 72 cases of case reports are shown in Table 3. The two forms have different properties: the raw HSW is used for detoxification, eliminating carbuncle, preventing malaria, and relaxing bowel, whereas the processed HSW is used for nourishing liver and kidney, supplementing essence and blood, blackening hair, strengthening bones and muscles, eliminating dampness, and reducing lipid [2]. Some clinical trials of HSW that reported liver damage were excluded for reasons originally given by Lao et al., specifically that they were too small to provide convincing evidence of rare complications [16]. 2020 Aug 6;12(8):2353. doi: 10.3390/nu12082353. Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine.  |  A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix. The length of hospitalization of case reports. Reports of hepatitis associated with Polygonum multiflorum have also been reported in the published literature (1–4). People should be alert to liver damage when taking HSW preparations. 2019 Sep 25;2019:5482896. doi: 10.1155/2019/5482896. Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. 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